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喉微生物组变化在sarcopenia:一个嵌套的病例对照研究在老年人
Runjie Li1,2, Wenhua Jiang3,4, Huiyu Tang1
1Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
萨科佩尼亚与口腔大微生物组的变化有关,显示出较低的多样性和促炎性特征. 这表明上呼吸道微生物组可能在沙科佩尼亚的发展中发挥作用.
科学领域:
- 微生物组研究 微生物组研究
- 老龄化和老年学
- 免疫学 免疫学 免疫学
背景情况:
- 萨科佩尼亚是一种肌肉损失的疾病,与炎症,呼吸系统问题和肠道微生物组失衡有关.
- 鼻和口 (NP/OP) 微生物组在肉症中的作用尚不清楚.
研究的目的:
- 为了研究NP/OP微生物组与养老院居民的肉病之间的关联.
- 为了确定与肉症相关的NP/OP通道中的特定微生物和功能变化.
主要方法:
- 一项嵌套病例对照研究,涉及120名参与者 (60名患有肉症,60名对照) 来自830名养老院居民的队列.
- 倾向性得分匹配被用来创建可比较的组.
- 用全长16S rRNA基因测序分析了鼻和口的拭子.
主要成果:
- 萨尔科佩尼亚与明显较低的口腔肠微生物α-多样性有关.
- 在sarcopenia中观察到一种亲炎性NP/OP微生物特征,其中包括Moraxella和Haemophilus等细菌的丰富,以及保护性种群的枯竭.
- 功能分析揭示了脂聚糖 (LPS) 生物合成的上调路径和短链脂肪酸 (SCFA) 和三甲代谢的下调路径.
结论:
- 口腔大微生物失调症,以减少多样性和促炎特征为特征,与肉症有关.
- 这项研究突出了上呼吸道微生物群和肉症之间的潜在联系.
- 对呼吸道-肠道-肌肉轴的进一步了解可能会为萨尔科佩尼亚及其与呼吸道疾病的联系提供新的见解.
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