在癌症患者中,多药性耐药性和尿路细菌病的复发
Ignacio Grafia1,2,3, Alba Moll-Febrer1, Solanche Jasmin Santillán4
1Medical Oncology Department, Hospital Clínic-IDIBAPS, Barcelona, Spain.
The Journal of antimicrobial chemotherapy
|September 19, 2025
概括
癌症患者的细菌性尿路感染 (bUTI) 通常是由格兰负菌根 (GNB) 引起的,导致高死亡率. 针对性的预防和优化的抗生素治疗对于管理这些具有挑战性的感染至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 细菌性尿路感染 (bUTI) 会增加癌症患者的发病率和死亡率.
- 了解瘤患者的bUTI特征对于改善结果至关重要.
研究的目的:
- 评估瘤患者中bUTI的特征,结果和复发情况.
- 为了确定多抗药性格拉姆阴性细菌 (MDR-GNB),复发性乳腺炎和相关死亡率的风险因素.
主要方法:
- 瘤患者bUTI发作的回顾性队列研究 (2008-2019).
- 用多变量回归模型来确定独立的风险因素.
主要成果:
- 在478名患者中发生了561例bUTI;87.3%是由GNB引起的.
- 19.6%的发作涉及MDR-GNB,23.4%接受了不适当的经验性抗生素治疗 (IEAT).
- 14.0%的患者经历了复发性肠炎;30天死亡率为15.3%.
结论:
- 癌症患者的bUTI主要是由GNB引起的,具有显著的MDR孤立和高死亡率.
- 较高的IEAT和复发率需要改进预防策略和经验治疗.
- 优化管理对于在这个脆弱人群中减少与BUTI相关的发病率和死亡率至关重要.
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