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Modeling the Functional Network for Spatial Navigation in the Human Brain
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大脑结构和功能改变 网络 视觉幻觉的定位

Yifan Li1,2,3,4, Fan Mo1,2,3,4, Chenglong Liu1,2,3,4

  • 1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Shushan District, Hefei 230022, China.

Schizophrenia bulletin
|September 19, 2025
PubMed
概括

视觉幻觉 (VH) 涉及广泛的大脑网络,特别是前端对象和注意力网络. 了解这些大脑网络的改变为改善VH治疗提供了潜力.

关键词:
大脑网络 大脑网络功能连接性的功能连接性磁共振成像技术的使用结构和功能结构和功能.视觉幻觉 - 视觉幻觉是一种幻觉.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经成像是一种神经成像.
  • 精神病学是一个精神病学.

背景情况:

  • 视觉幻觉 (VH) 是神经退行性和精神疾病的重要症状,通常表明预后更差.
  • 目前的理解表明VH涉及相互连接的大脑网络,而不是孤立的区域.
  • 关于VH的特定大脑网络本地化存在有限的研究.

研究的目的:

  • 识别和绘制与视觉幻觉相关的特定大脑网络.
  • 提供基于网络的神经生物学理解VH.
  • 探索VH的潜在治疗点.

主要方法:

  • 系统审查了21项神经成像研究,以确定418名VH患者的结构和功能变化.
  • 应用功能连接网络映射到大型静止状态fMRI数据集 (发现n=1113,验证n=1093).
  • 绘制特定的大脑改变到特定的功能性大脑网络.

主要成果:

  • 在VH中,结构性变化主要与前侧平行和背侧注意力网络有关.
  • 在VH中,功能性改变主要涉及腹部注意力和前侧对称网络.
  • 结构和功能上的改变都分布在这些网络中的大脑区域中.

结论:

  • VH与特定的,相互连接的大脑网络的变化有关,特别是前端对象和注意力网络.
  • 这种网络层面的理解完善了VH的神经生物学.
  • 这些发现可能有助于开发针对视觉幻觉的更有针对性的治疗方法.