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在布拉汉牛群中进行妊娠损失的基因组研究

Sabrina T Amorim¹, Nedenia Bonvino Stafuzza², Daniel Cardona Cifuentes³

¹Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078.

Journal of animal science

|September 19, 2025

概括

遗传因素影响了布拉汉牛的妊娠损失 (PL). 识别这些遗传区域和基因可以改善生殖表现,提高群体的生产力.

科学领域:

动物遗传学动物遗传学
生殖生物学生殖生物学
基因组学就是基因组学.

背景情况:

生殖效率显著影响肉牛的生产率和利能力.
孕期流产 (PL) 是畜牧业经营的一个主要经济问题,影响着牛群的效率.
了解PL的遗传基础对于开发有效的育种策略至关重要.

研究的目的:

为了估计布拉汉牛中PL的方差成分.
确定与PL相关的基因组区域和候选基因.
探索影响肉牛繁殖成功的遗传因素.

主要方法:

利用了29905个表型记录 (怀孕和堕胎).
使用中密度SNP芯片 (52K标记器) 基因型921只动物.
应用了一步基因组BLUP与差异组件估计和GWAS的值模型.

主要成果:

估计PL的低遗传率 (0.11),表明存在遗传变异.
在各种染色体 (BTA4,7-9,11,12,16,18,19,21,22,29) 上确定了17个候选区域,其中包含92个基因.
发现了与胚胎发育,植入,受精和信号通路相关的基因,与人类和动物 ортолог.

结论:

为了改善布拉曼牛的生殖表现,基因选择是可行的.
候选区域和基因提供了标记器辅助选择的目标,以减少PL.
这些发现有助于更好地了解牛妊娠延迟的遗传和生理机制.

关键词:

森林的表示 Bos indicus.在GWAS中,GWAS就是GWAS.堕胎堕胎堕胎堕胎堕胎堕胎堕胎堕胎遗传参数遗传参数生殖效率提高的生殖效率.

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