关于在炎症性肠病试验中使用肠道超声波的国际共识
Mariangela Allocca1, Vipul Jairath2, Bruce E Sands3
1IRCCS Hospital San Raffaele and University Vita-Salute San Raffaele, Gastroenterology and Endoscopy, Milan, Italy.
在炎症性肠病 (IBD) 试验中为肠道超声波 (IUS) 建立了标准化定义. 这种共识为评估克罗恩病和性结肠炎的治疗反应和缓解提供了明确的IUS终点.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 临床试验 临床试验
背景情况:
- 肠道超声波 (IUS) 越来越多地用于炎症性肠病 (IBD) 临床试验.
- 目前还没有基于IUS的响应,缓解和评估时间的标准化定义.
- 为了解决这些差距,召开了一次国际专家共识会议.
研究的目的:
- 建立标准化肠道超声波 (IUS) 终点,用于炎症性肠病 (IBD) 临床试验.
- 根据IUS参数定义治疗反应和缓解的标准.
- 在IBD试验中推IUS评估的最佳时间.
主要方法:
- 一个经过修改的德尔菲工艺,涉及35名国际胃肠道学家和放射学家.
- 文献审查和制定共识陈述,达成≥75%的协议门.
- 专注于四个领域:一般IBD,光线克罗恩病 (CD),围CD和性结肠炎 (UC).
主要成果:
- 在四个IBD领域的150个陈述达成共识.
- 对光线CD和UC的定义超声响应,包括肠壁厚度 (BWT) 和颜色多普勒信号 (CDS).
- 确定的评估时间 (结肠4-8周,末端大肠12周) 和缓解标准,包括特定的BWT值和多个参数的规范化. 支持BUSS和MUC作为标准化的评分系统.
结论:
- 该共识提供了标准化的IUS定义,对于IBD临床试验的一致性至关重要.
- 这些定义有助于将IUS纳入未来IBD研究中作为可靠的结果指标.
- 提高IUS的实用性,用于监测IBD治疗疗效.
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