断奶后增长率的增加影响了两岁母羊在第二次怀孕和哺乳期间的乳腺基因表达
Emmanuelle Haslin1,2, Hitihamy M G P Herath2, Sarah J Pain2
1Centre for Animal Production and Health, Murdoch University, Murdoch Western Australia, Australia.
Journal of animal science
|September 19, 2025
概括
年轻母羊的增长速度增加可能会影响乳腺基因表达,特别是减少用于牛奶脂肪合成和细胞分化的关键基因. 然而,在本研究中,这些变化并没有影响羔羊的生长或乳腺的整体发育.
科学领域:
- 动物科学动物科学
- 遗传学和基因组学 遗传学和基因组学
- 生殖生物学 生殖生物学
背景情况:
- 早期的生长轨迹可以影响以后的生理功能.
- 乳腺的发育和功能对于哺乳期的表现至关重要.
- 了解与生长相关的基因表达变化对于优化畜牧生产至关重要.
研究的目的:
- 调查早期发育期间加速生长率对母羊第二次哺乳期间乳腺基因表达的长期影响.
- 确定参与乳腺细胞发育和牛奶脂肪代谢的特定基因,这些基因可能会受到早期生长速度的影响.
- 评估早期生长对乳腺功能和羊羔表现的潜在转移效应.
主要方法:
- 选择了19只双胞胎母羊,根据3-7个月龄之间的生长,分为"重" (增长速度) 和"对照"组.
- 在怀孕128天和哺乳期30天收集的乳腺活检.
- 利用NanoString nCounter技术分析了与乳腺发育和牛奶脂肪代谢相关的37个基因的表达.
主要成果:
- 早期生长速度增加的母羊表现出一种倾向于较低地表达乙基-A合成酶短链家族成员1 (ACSS1),这对乳脂合成至关重要.
- 在重组中观察到信号转换器和转录激活器5A (STAT5A),乳腺上皮细胞分化的调节器的表达率较低的趋势.
- 在羊羔的生长,活体重或下游基因表达方面没有发现显著的表型差异,这表明功能影响有限.
结论:
- 生命早期的加速生长可能会导致母羊在特定乳腺基因表达的微妙,长期变化.
- 尽管基因表达趋势,但早期生长率并没有显著影响乳腺发育或第二次哺乳期羊羔的表现.
- 建议采用全面的转录组分析和功能性哺乳评估进行进一步的研究,以充分阐明对母羊乳功能和牛奶成分的影响.
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