相关实验视频
Updated: Jan 17, 2026

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Murine Kidney Transplant Technique
Published on: October 20, 2015
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两例移植后的血栓性微血管病变,来自单一的献血者,患有白血病
Tiffany Shi1, William H Schwieterman2, Olanrewaju Eletta2
1Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Transplantation proceedings
|September 19, 2025
概括
在移植后引起血栓性微血管病变 (TMA) 的捐赠者衍生的真菌感染具有挑战性. 尽管进行了治疗,但两例病例的结果不佳,这凸显了需要更好的治疗策略的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 移植后的血栓式微血管病 (TMA),特别是来自捐赠者的感染,可能导致移植损失和死亡.
- 来自捐赠者的真菌感染,特别是Candida,在移植受体中提出了诊断和治疗方面的挑战.
研究的目的:
- 描述两例移植后的TMA二次性病例,该病例发生在怀疑患有候选血症的单个捐赠者身上.
- 突出在器官移植和真菌感染的背景下管理TMA的困难.
主要方法:
- 案例报告两名脏移植接受者发展了TMA.
- 治疗包括预防性可纳用于Candida和eculizumab用于TMA.
主要成果:
- 一名患者死于与TMA相关的并发症.
- 第二名患者经历了持续的血解,需要移植切除术以改善症状和实验室价值.
- 两名患者都接受了针对Candida和TMA的标准治疗,结果不利.
结论:
- 与捐赠者衍生的血症相关的TMA在移植中带来了重大挑战.
- 在这种情况下,目前对TMA和候选血症的治疗策略可能不足,需要进一步研究新的治疗方法.
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