定义便calprotectin截止值,预测型结肠炎患者内镜和组织学缓解
Gustavo Drügg Hahn1,2,3, Peter Laszlo Lakatos1,4, Chelsea Maedler-Kron5
1Division of Gastroenterology, Department of Medicine, McGill University, Montreal, QC, Canada.
Inflammatory bowel diseases
|September 19, 2025
概括
便中的calprotectin水平与性结肠炎疾病活性相关. 这项研究确定了便calprotectin的最佳切割值,以确定性结肠炎患者的体内膜学缓解.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 临床生物标志物研究研究
背景情况:
- 便中的calprotectin是性结肠炎 (UC) 活性的一个关键标志物.
- 缺少共识的截止值用于体内膜学缓解.
- 这项研究将便calprotectin与内镜和组织学UC活性相关联.
研究的目的:
- 为了确定最佳便calprotectin截止值,以评估UC患者的组织内镜缓解.
- 为了将便calprotectin水平与梅奥内镜评分和吉博斯组织学评分相关联.
- 评估便calprotectin作为UC疾病活动的替代标记物.
主要方法:
- 对253名成人UC患者 (2013-2020年) 的前性研究.
- 在结肠镜检查期间收集了便calprotectin和Mayo内镜分数.
- 通过盲目的病理学家使用Geboes评分评估组织学活动.
主要成果:
- 便calprotectin≥123μg/g预测梅奥内镜评分>0 (58%的灵敏度,70%的特异性).
- 便calprotectin ≥80μg/g在临床缓解期患者中识别了Geboes评分>3.1 (64.7%的灵敏度,58.7%的特异性).
- 便calprotectin≥50μg/g是最佳的在临床缓解 (49.6%的灵敏度,41.6%的特异性) 时识别活跃的组织学炎症 (吉博斯评分>2).
结论:
- 便calprotectin有效地与UC中的内镜和组织学疾病活性相关.
- 已建立的最佳便calprotectin截止值可以区分体内镜缓解.
- 便calprotectin作为一个有价值的替代标志物用于UC疾病活动评估.
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