周围神经侵入影响非小细胞肺癌复发的风险和复发模式
Beatrice Chia-Hui Shih1, Woohyun Jung1, Jeong Hoon Lee2
1Division of Thoracic Surgery, Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, 13620, Republic of Korea.
概括
周围神经侵入 (PNI) 显著增加非小细胞肺癌 (NSCLC) 的复发风险,特别是在早期阶段. 在NSCLC患者中,PNI也与更频繁的胸外复发有关.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 癌症流行病学 癌症流行病学
背景情况:
- 周围神经侵袭 (PNI) 是各种癌症的一个公认的预后因素.
- 它对非小细胞肺癌 (NSCLC) 复发模式的具体影响需要进一步阐明.
研究的目的:
- 评估围神经侵入 (PNI) 与手术切除非小细胞肺癌 (NSCLC) 患者复发的风险和模式之间的关联.
主要方法:
- 对5545名切除I-III期NSCLC患者 (2009-2021) 的回顾性分析.
- PNI定义为神经内的瘤细胞或涉及神经周长的≥33%.
- 在PNI阳性和PNI阴性组之间比较无复发生存率和复发模式.
主要成果:
- 在5.3%的患者中存在PNI,在I-III阶段的患病率越来越高.
- 阳性PNI患者的预后因素较差,并且5年后复发的累积发病率明显较高 (42.4%与16.5%相比).
- 在I-II期NSCLC中,PNI增加了复发风险,并且与更频繁的胸外复发有关.
结论:
- 围神经侵入是NSCLC复发风险增加的重要预测因素,特别是在早期阶段.
- 在NSCLC中PNI的存在与胸外复发的可能性更高相关.
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