相关实验视频

Updated: Jan 17, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

在小鼠中,TNFSF15减轻了由骨髓细胞衍生的抑制细胞介导的癌症免疫抑制作用

Yi-Pan Zhu¹, Jing Sun¹, Xin-Yu Cao¹

¹State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, The Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China.

Acta pharmacologica Sinica

|September 19, 2025

概括

在路易斯肺癌小鼠中,重组瘤坏死因子超级家族成员15 (TNFSF15) 治疗显著降低了骨髓原抑制细胞 (MDSCs). 这种免疫疗法方法还通过促进MDSC分化和增强T细胞活性来抑制瘤生长.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
分子生物学分子生物学

背景情况:

骨髓原抑制细胞 (MDSCs) 是各种病理状况中免疫抑制的关键调节者,包括癌症.
瘤坏死因子超级家族成员15 (TNFSF15) 参与免疫调节,血管调节和免疫细胞分化.

研究的目的:

调查复合TNFSF15在减少MDSC积累在易斯肺癌 (LLC) 鼠标模型中的有效性.
阐明TNFSF15影响MDSC种群和抗瘤免疫力的机制.

主要方法:

路易斯肺癌全移植模型小鼠接受了重组TNFSF15.15的治疗.
瘤,骨髓和脏组织使用流动细胞计和免疫光染色进行了分析.
评估了JAK1/STAT3信号通路的激活.

主要成果:

TNFSF15治疗显著抑制了LLC瘤的生长,并减少了MDSC在瘤,骨髓和脏中的积累.
减少MDSCs主要归因于单细胞样MDSC (M-MDSC) 亚型,观察到巨细胞和树突细胞 (DCs) 的比例增加.
TNFSF15通过JAK1/STAT3信号通路促进了M-MDSC分化,导致细胞毒性T细胞积累增加和瘤生长抑制.

结论:

在LLC模型中,重组TNFSF15有效降低MDSC积累,并抑制瘤生长.
TNFSF15促进M-MDSC分化为DC和巨细胞,从而增强抗瘤T细胞的反应.
TNFSF15代表了调节瘤微环境和恢复抗瘤免疫力的有前途的治疗剂.

关键词:

易斯肺癌肺癌是什么?在MDSC中,MDSC是MDSC.这就是T细胞.美国TNFSF1515 树突细胞的树突细胞.不同化的差异化差异化.巨细胞是什么?巨细胞是什么?

更多相关视频

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.