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遗传培养对抑郁和焦虑障碍和症状以及相关特征的影响
Victória Trindade Pons1, Albertine J Oldehinkel2, Hanna M van Loo2
1Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. v.trindade-pons@umcg.nl.
Molecular psychiatry
|September 19, 2025
概括
父母的基因导致后代的抑郁和焦虑,主要是通过直接遗传,而不是间接的遗传培养途径. 这项研究发现,遗传培养对这些心理健康状况产生影响的证据很少.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 父母患有抑郁症和焦虑症的后代有较高的风险.
- 父母基因可能通过直接遗传和间接的"遗传培养"环境途径影响后代.
- 关于遗传培养在抑郁症和焦虑症的家族传播中的作用的数据有限.
研究的目的:
- 研究遗传培养在抑郁和焦虑的家族传播中的作用.
- 要区分直接的遗传传染和间接的遗传培养效应.
主要方法:
- 利用了来自生命线队列中的15231-17186名荷兰成年人与基因型父母的数据.
- 针对抑郁症的传染性 (PGS-T) 和非传染性 (PGS-NT) 家长单元型的计算多基因分数.
- 使用混合效应回归模型分析了PGS-T,PGS-NT和后代结果 (疾病,症状,神经病,负面影响) 之间的关联.
主要成果:
- 在PGS-T和后代结果之间发现了显著的关联,支持直接遗传 (OR = 1.2-1.5).
- 在所有测量结果中,PGS-NT效应在很大程度上是零的,这表明遗传培养的作用很小.
- 在特定的评估波中观察到PGS-NT的一些小例外,但对遗传培养的总体证据很弱.
结论:
- 遗传培养似乎在抑郁症和焦虑症,症状和相关特征的家族传播中起到很小的作用.
- 抑郁和焦虑的基因传播的主要方式可能是直接遗传.
- 进一步的研究可能会探索通过其他遗传风险因素的间接遗传影响,但直接遗传是被确定的主导途径.
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