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Updated: Jan 17, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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从使用IRF3作为适配器的晚期内酶体区向NF-κB发送STING信号

Bao-Cun Zhang1,2, Alice Pedersen3, Line S Reinert3,4

  • 1Department of Biomedicine, Aarhus University, Aarhus, Denmark. baocunzh@biomed.au.dk.

Nature immunology
|September 19, 2025
PubMed
概括

STING通过IRF3激活NF-κB,在一个涉及内酶体的延迟途径中. 这种依赖IRF3和TRAF6的保存免疫机制在特定时间窗口内发生,以调节炎症.

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