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Updated: Jan 17, 2026

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依赖ATP的单维运动通过抑制自发的MDA5丝组装来维持免疫平衡

Xiao-Peng Han1, Ming Rao1, Yu Chang2,3,4

  • 1State Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

Cell research
|September 20, 2025
PubMed
概括

作为一个关键的免疫传感器,MDA5沿着病毒的dsRNA像电机一样移动. 它的调节运动和与LGP2的相互作用对于启动免疫反应和维持平衡至关重要.

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