与瘤相关的纤维细胞调节尿癌的进展
Yu Xiao1,2, Junfeng Yang1,2, Mengjie Sun1,2,3
1The Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, Kunming 650500, China.
Journal of molecular cell biology
|September 20, 2025
概括
与癌症相关的纤维细胞 (CAFs) 通过激活瘤细胞来驱动上道泌尿道癌 (UTUC) 的进展. 这些发现揭示了CAF是UTUC的关键参与者,并确定了膀癌的共享预后标志物.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 已知与癌症相关的纤维细胞 (CAF) 影响瘤生长和转移.
- 对于CAFs在上道泌尿道癌 (UTUC) 的发展中的特定作用尚不清楚.
- 了解瘤微环境对于开发有效的癌症疗法至关重要.
研究的目的:
- 研究CAFs在上道泌尿道癌 (UTUC) 进展中的作用.
- 构建一个全面的微环境地图的CAFs在UTUC.
- 为了确定UTUC和膀泌尿腺癌 (BUC) 的潜在预后标志物.
主要方法:
- 使用单细胞RNA测序 (scRNA-seq),单核RNA测序 (snRNA-seq) 和空间增强分辨率的奥米克测序 (立体测序).
- 分析了一组UTUC免疫光芯片队列.
- 将瘤上皮细胞分为高,中,低恶性潜在类别,使用层次聚类和副本数变异 (CNV) 评分.
主要成果:
- 确定了肌纤维细胞CAFs (myCAFs1和myCAFs2),这些CAFs与UTUC的所有上皮细胞类型有显著的相互作用.
- 发现了高恶性上皮细胞 (HMEC) 和CAF之间明显的通信信号,由FN1和COL1A1.1驱动.
- 证明myCAFs1和myCAFs2对UTUC和膀泌尿腺癌 (BUC) 的预后都有影响,在所有队列中具有一致的风险模型.
结论:
- CAFs,特别是myCAFs1和myCAFs2,在激活瘤细胞和推动UTUC进展方面发挥着至关重要的作用.
- 该研究提供了TUC微环境的第一个全面的多学科景观.
- 确定了UTUC和BUC共享的共同预后标志物,表明了潜在的治疗点.
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