开始的年龄,大脑可控性和工作记忆表现在第一发精神分裂症中的表现
Feiwen Wang1, Zhening Liu1, Jun Yang1
1Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Schizophrenia bulletin
|September 20, 2025
概括
精神分裂症开始的年龄在工作记忆任务期间显著影响大脑网络的可控性. 这项研究揭示了早期发作的精神分裂症与成人发作的精神分裂症如何不同地影响大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症发病年龄影响认知缺陷,特别是工作记忆 (WM).
- 大脑网络可控性,这是状态过渡动态的衡量标准,随着年龄和发育而变化.
- 了解发病年龄对大脑可控性的影响对于解释精神分裂症中WM缺陷至关重要.
研究的目的:
- 研究精神分裂症发病年龄对大脑网络可控性的影响.
- 确定大脑可控性,工作记忆性能和临床特征之间的关系.
- 探索精神分裂症中改变大脑可控性的遗传基础.
主要方法:
- 在早期发作的精神分裂症 (EOS),年轻的健康对照 (yHC),成人发作的精神分裂症 (AOS) 和老年健康对照 (oHC) 中在N-back任务中检查了大脑连接体的平均和模式可控性.
- 通过全脑分析确定了患病和发病年龄相互作用的大脑区域.
- 与WM性能和临床数据相关的可控性,随后进行基因注释分析.
主要成果:
- 在传感运动,听觉,皮质下,默认模式,视觉和突出网络中发现了可控性的重大疾病*发病年龄相互作用.
- 特定的网络效应与成人开始精神分裂症 (AOS) 与老年健康对照 (oHC) 以及早期开始精神分裂症 (EOS) 与年轻健康对照 (yHC) 相关.
- 在可控性和认知表现或临床症状之间没有观察到显著的相关性;然而,受影响的区域显示了与突触信号和神经退行相关的基因表达.
结论:
- 精神分裂症发病年龄在工作记忆任务期间对大脑状态过渡可控性的异质性有显著的贡献.
- 这些发现突出了与不同精神分裂症发病年龄相关的独特神经机制.
- 这项研究强调了考虑发病年龄的重要性,以了解精神分裂症的神经生物学基础和认知影响.
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