婴儿时期的血清类固醇代谢组动态:健康婴儿的纵向队列研究
Alexander Siegfried Busch1,2,3, Marie Lindhardt Ljubicic2,3, Emmie N Upners2,3
1Department of General Pediatrics, University of Münster, 48149 Münster, Germany.
European journal of endocrinology
|September 20, 2025
概括
婴儿的类固醇激素水平在第一年发生显著变化,皮质醇增加,而其他水平下降. 这些发现为诊断类固醇生成障碍建立了参考曲线.
科学领域:
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
- 儿科研究 儿科研究
背景情况:
- 婴儿期涉及显著的类固醇代谢转移由于上腺皮质的发展和小青春期.
- 使用LC-MS/MS的婴儿类固醇配置文件的纵向数据有限.
- 了解这些变化对于诊断婴儿内分泌疾病至关重要.
研究的目的:
- 在健康的婴儿中绘制血清类固醇代谢的时间动态图.
- 建立婴儿类固醇激素的性别和年龄特定的参考曲线.
- 提供婴儿类固醇生成的综合性特征.
主要方法:
- 未来的,纵向的出生队列研究 (哥本哈根迷你青春期研究).
- 用LC-MS/MS测量了189名婴儿 (88名女孩,101名男孩) 的16种类固醇激素的血清水平.
- 特定年龄的参考值是使用通用附加模型 (GAMLSS) 建模的.
主要成果:
- 观察到明显的婴儿类固醇代谢模式:皮质醇和11-deoxycorticosterone的增加,孕激素和雄激素的减少.
- 大多数趋势是独立于性别的,除了男孩的17β-hydroxysteroid脱酶活性更高.
- 在关键的类固醇生成酶活动中没有发现任何显著的性别差异,除非性别类固醇转化.
结论:
- 婴儿血清类固醇代谢组在生命的第一年全面的表征.
- 开发的特定年龄的参考曲线有助于诊断和监测罕见的类固醇生成障碍.
- 这些发现支持了解婴儿内分泌发育和疾病的临床应用.
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