口腔癌风险分层:印度东北地区基于人口的横截面查研究
Kunal Oswal1, Satirtha Barman2, Alexandar R Kerr3
1Karkinos Healthcare Private Limited, Mumbai, India.
International journal of cancer
|September 20, 2025
概括
烟草袋角质炎可能表明早期的口腔癌风险,建议采取行为干预措施. 一个开发的风险预测模型在内部表现有希望,但由于地理差异,在外部验证方面面临挑战.
科学领域:
- 口腔瘤学 在口腔瘤学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 口腔癌是一个重大的健康问题,特别是在印度东北部.
- 烟草囊角膜炎是一种常见的口腔病变,但其作为口腔癌前期/癌症早期指标的作用需要进一步调查.
研究的目的:
- 开发和验证印度东北部口腔癌前期/癌症的风险预测模型.
- 为了比较烟草袋角质炎的流行病学概况与口腔癌前期/癌症.
- 评估烟草袋角质炎作为早期致癌事件的潜力.
主要方法:
- 一项涉及14749名参与者的横截面研究,采访者管理问卷和口腔检查 (视觉检查,自发光).
- 后勤回归分析用于风险因素比较和模型开发.
- 风险预测模型的内部和外部验证.
主要成果:
- 患病率:良性病变 (1.6%),烟草袋角质炎 (5.4%),癌前病变/癌症 (2.2%).
- 牙医和卫生工作者在视觉诊断方面达成高度一致 (kappa=0.77).
- 风险预测模型显示出良好的内部歧视 (AUC=0.83) 和校准,识别高风险个体.
- 外部验证显示了适度的歧视 (AUC=0.67) 和糟糕的校准,表明运输能力有限.
结论:
- 烟草袋角质炎可能代表早期致癌事件,突出了行为干预的机会.
- 风险模型的外部验证不足强调了需要地理特定模型来考虑印度风险因素的区域变化.
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