食品矩阵对Lacticaseibacillus rhamnosus CRL1505在胃肠道中存活的影响:一个随机,受控,交叉研究
Nicola Mangieri1, Viola Termine1, Giorgio Gargari1
1Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy.
Molecular nutrition & food research
|September 20, 2025
概括
益生菌 Lacticaseibacillus rhamnosus CRL1505 在发酵的麦和牛奶饮料中存活得更好. 这项研究表明,食物矩阵可以通过肠道增强益生菌的传递和生存.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 食品科学 食品科学 食品科学
背景情况:
- 益生菌的有效性取决于通过胃肠道的生存.
- 关于传递格式如何影响益生菌生存能力的研究有限.
- 乳酸酶菌cillus rhamnosus (L. rhamnosus) CRL1505是一种感兴趣的益生菌菌株.
研究的目的:
- 为了评估L. rhamnosusCRL1505.5.的胃肠道存活率.
- 为了比较作为冷干燥细胞和发酵麦和牛奶饮料中的生存率.
- 评估食品矩阵对益生菌生存能力的影响.
主要方法:
- 健康的志愿者在不同的形式中消耗了L. rhamnosus CRL1505 (≥10亿CFU/天).
- 使用基于培养和分子技术测量了益生菌生存率.
- 便样本被分析使用metataxonomic分析来评估微生物群的变化.
主要成果:
- 与冷干燥细胞相比,L. rhamnosus CRL1505在麦和牛奶发酵饮料中的生存率显著更高.
- 益生菌菌株在一小组志愿者中持续了给药后一周.
- 在治疗组中没有观察到便微生物群多样性的显著变化.
结论:
- 食品矩阵,特别是发酵的麦和牛奶,在胃肠道过境期间显著提高了L. rhamnosus CRL1505的存活率.
- L. rhamnosus CRL1505菌株在人类肠道中表现出强大的生存能力,即使没有保护性食物矩阵.
- 选择合适的食物矩阵对于优化益生菌活力和功能性食品的潜在有效性至关重要.
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