怀孕后的疾病过程在患有进展性多发性硬化症症状的妇女中
Jessica Shipley1,2, Heidi N Beadnall3, Paul G Sanfilippo1
1Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
概括
怀孕在患有初级渐进性多发性硬化症 (PPMS) 或二级渐进性多发性硬化症 (SPMS) 的女性中不会显著改变长期残疾. 这一发现为考虑怀孕的进展性多发性硬化症妇女提供了保证.
科学领域:
- 神经学 神经学
- 生殖健康 生殖健康
- 临床研究 临床研究
背景情况:
- 渐进性多发性硬化症 (MS) 现型,包括初级渐进性MS (PPMS) 和次级渐进性MS (SPMS),对怀孕期间的疾病结果的影响尚不清楚.
- 描述怀孕对MS妇女疾病进展的影响对于知情的临床管理至关重要.
研究的目的:
- 为了调查患有PPMS或SPMS的妇女的临床特征和疾病过程,这些妇女在诊断后经历了怀孕.
- 评估怀孕对进展性多发性硬化症表型妇女残疾进展的长期影响.
主要方法:
- 一项使用国际MSBase注册表数据的多中心观察队列研究.
- 倾向性得分匹配与有或没有怀孕史的进展性多发性硬化症妇女进行了比较.
- 扩展残疾状况尺度 (EDSS) 评分被评估到分娩后10年.
主要成果:
- 包括138名164个怀孕的妇女 (75名PPMS,63名SPMS).
- 在患有PPMS的女性中,怀孕史与长期残疾轨迹没有显著的关联 (估计=-0.02;95%CI=-0.07至0.04).
- 怀孕史也没有显示出与SPMS妇女的长期残疾轨迹的显著关联 (估计=0.00;95%CI=-0.02至0.03).
结论:
- 怀孕史与进展性多发性硬化症妇女长期残疾的显著差异无关.
- 这些发现表明,怀孕不会对患有PPMS或SPMS的女性的长期疾病过程产生负面影响.
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