维生素D缺乏,艾滋病毒和慢性肝病的交叉点
Francesca Farina1,2,3, Aurgho Datta1, Suzanne N Morin4
1Chronic Viral Illness Service, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada.
HIV medicine
|September 20, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是艾滋病毒感染者的一个主要问题. 维生素D缺乏是常见的,可能会恶化肝病,因此需要进一步的研究和综合护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 慢性肝病,特别是与代谢功能障碍相关的脂肪性肝病 (MASLD),是艾滋病毒感染者死亡的主要原因,即使有有效的抗逆转录病毒疗法 (ART).
- 维生素D缺乏在艾滋病毒感染者中非常普遍,并且与一般人群中MASLD和肝纤维化有关.
研究的目的:
- 综合当前关于艾滋病毒感染,肝病 (特别是MASLD) 和维生素D缺乏之间的复杂相互作用的证据.
- 突出对风险分层和艾滋病毒感染者的未来治疗研究的影响.
主要方法:
- 使用与艾滋病毒,肝脏疾病,纤维化和维生素D相关的关键词,对PubMed进行了有针对性的文献搜索.
- 来自非艾滋病毒人口的同行评审研究,指导方针和比较数据被优先考虑,以了解流行病学,病变发生和关联.
主要成果:
- 艾滋病毒感染者有较高的肝病负担,主要由MASLD,并发感染和肝毒性暴露驱动.
- 病原发生涉及免疫激活,炎症和肝星细胞激活.
- 维生素D缺乏症在艾滋病毒感染者中很常见,新出现的证据表明,通过免疫调节和氧化应激,可能与MASLD和纤维化有关,尽管因果关系尚未被证明.
结论:
- 艾滋病毒,MASLD和维生素D缺乏的交叉是临床相关的,但需要进一步调查.
- 需要进行纵向研究来确定因果关系和最佳管理策略.
- 整合代谢风险和维生素D评估可能会改善艾滋病毒感染者的肝脏护理,并且需要进行干预试验来评估维生素D的治疗潜力.
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