乳酸和乳酸化在瘤免疫中的作用
Liu Song1,2, Lingjuan Sun3, Song Chen4,5
1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Frontiers of medicine
|September 20, 2025
概括
乳酸盐是癌症中华堡效应的产物,抑制了瘤微环境 (TME) 中的免疫细胞. 向乳酸提供了一个新的策略,用于开发有效的免疫抑制癌症疗法.
科学领域:
- 癌症新陈代谢 癌症新陈代谢
- 免疫学 免疫学 免疫学
- 瘤微环境 (TME) 是指瘤的微环境.
背景情况:
- 沃伯格效应描述了瘤细胞的新陈代谢重编程到糖解,导致快速的能量产生.
- 这种新陈代谢转移导致乳酸的积累,形成酸性瘤微环境 (TME).
- 酸性TME会损害免疫细胞的功能,并促进瘤的进展.
研究的目的:
- 在TME中全面审查乳酸作为免疫抑制分子的作用.
- 阐明乳酸调节免疫细胞功能的机制.
- 突出乳酸在TME内的免疫调节的重要性,以获得新的治疗见解.
主要方法:
- 文献综述侧重于乳酸对TME中免疫细胞的影响.
- 检查分子机制,包括膜受体结合和乳酸穿运输.
- 通过基因素和非基因素乳化对表观遗传调节的分析.
主要成果:
- 乳酸作为一个关键的免疫抑制信号分子在TME.
- 乳酸酸通过各种机制影响免疫细胞功能,包括受体结合和运输.
- 表观遗传修饰,如乳酸化,参与了乳酸介导的免疫抑制.
结论:
- 乳酸在瘤微环境中的免疫抑制中起着至关重要的作用.
- 了解乳酸的免疫抑制功能为开发向治疗提供了基础.
- 向乳酸为开发有效的免疫抑制癌症治疗提供了新的见解.
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