在3067名丹麦BRCA1/2携带者中进行风险降低手术的时间趋势,吸收率和瘤影响:基于人口的研究,与匹配的对照进行了基于人口的研究
Cecilie Balslev Willert1, Lene Mellemkjær2, Anders Tolver3
1Department of Plastic Surgery, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls Vej 5, 2730 Herlev, Herlev, Denmark. cecilie.balslev.willert@regionh.dk.
双边降低风险的乳腺切除术 (BRRM) 显著降低了BRCA1/2携带者的乳腺癌风险. 卵管切除术 (RR-BSO) 没有表现出类似的保护作用,但BRRM可能会降低整体死亡率.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 预防医学 预防医学
背景情况:
- BRCA1/2基因突变显著增加了乳腺和卵巢癌的风险.
- 降低风险的手术,如双边降低风险的乳房切除术 (BRRM) 和salpingo-oophorectomy (RR-BSO) 是载体的选择.
- 了解这些手术的吸收率和有效性对于患者咨询至关重要.
研究的目的:
- 分析丹麦未受影响的BRCA1/2载体中BRRM和RR-BSO吸收的趋势.
- 评估BRRM和RR-BSO在这个队列中的乳腺癌预防和生存效应.
- 为了将瘤结果与匹配的对照进行比较.
主要方法:
- 一项全国性的队列研究,包括3067名女性BRCA1/2携带者和30652名对照者 (2000-2022年).
- 来自国家卫生登记册的数据.
- 使用累积发病率和Cox比例危险模型评估的摄入量和瘤影响.
主要成果:
- 随着时间的推移,BRRM和RR-BSO的年度采用量有所增加.
- 经过BRRM治疗,乳腺癌风险率降低了94% (HR 0.06).
- RR-BSO没有显示出保护作用 (HR 1.31);BRCA1/2携带者在BRRM之前患乳腺癌的风险更高 (HR 7.49).
结论:
- 在BRCA1/2载体中,BRRM提供了对乳腺癌的大量保护作用.
- 在这项研究中,没有证实RR-BSO对卵巢癌的保护作用.
- BRRM显示总体死亡率下降的趋势,在手术前观察到更高的死亡率.
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