从暴露到致病:对SCCP诱导的毒性和潜在的分子机制进行了批判性审查
Liyong Kou1, Hong Qi2, Yi Jiang3
1Department of General Practice, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214000, People's Republic of China.
Ecotoxicology and environmental safety
|September 20, 2025
概括
短链甲 (SCCP) 是人类中发现的持久性污染物,具有器官损伤和癌症等风险. 健康风险评估对于管理这些环境污染物至关重要.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 短链化 (SCCP) 是一种工业化学品,具有很高的稳定性,但涉及环境持久性.
- 由于生物积累,远程运输和毒性,SCCPs在斯德哥尔摩公约下被认定为持久有机污染物 (POP).
- 尽管存在全球限制,但SCCP的生产和使用在一些地区仍然存在,导致人类广泛暴露.
研究的目的:
- 综合审查SCCPs的暴露途径,人类积累和毒理机制.
- 专注于SCCP对各种器官系统和代谢过程的特定毒性影响.
- 突出慢性SCCP暴露对公共健康的影响,并提出未来研究方向.
主要方法:
- 对SCCP暴露,毒性和人类存在的现有研究的文献综述.
- 对与疾病生物标志物相关联的SCCP水平的流行病学数据的分析.
- 综合有关毒性机制的信息,包括对代谢障碍和信号通路的影响.
主要成果:
- 在人体样本中无处不在检测到SCCP,包括血液,头发和带.
- 对SCCP的暴露与代谢障碍,肝脏和脏毒性以及癌症风险增加有关.
- 有证据表明,血清SCCP水平与某些疾病的生物标志物之间存在相关性,这表明潜在的健康危害.
结论:
- 长期暴露于SCCP引起了全球重大公共卫生问题,需要进行全面的风险评估.
- 未来的研究应该整合人类暴露学,计算毒理学和有机物技术,用于预警和管理.
- 作为持久性有机污染物,SCCP的有效全球管理对于减轻健康风险至关重要.
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