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臭氧暴露,视网膜微血管结构的改变,以及糖尿病人群中衰老的调解作用:一项回顾性队列研究

Senlin Lin¹, Xia Meng², Yi Xu¹

¹Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, Hongqiao Road, No 1440, Shanghai, China; Eye Public Health Research Center, School of Medicine, Tongji University; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai, China.

Ecotoxicology and environmental safety

|September 20, 2025

概括

长期暴露于臭氧会加速视网膜衰老,改变微血管结构,增加脑心血管风险. 这项研究将空气污染与2型糖尿病患者的眼睛健康变化联系起来.

科学领域:

环境健康环境健康
眼科医生眼科眼科
心血管研究研究心血管研究

背景情况:

流行病学研究将臭氧暴露与脑心血管疾病联系起来.
视网膜微血管结构的变化是系统内皮功能障碍和脑心血管事件预测的敏感指标.
臭氧对微血管的影响,特别是在2型糖尿病患者 (T2DM) 等弱势群体中,需要进一步描述.

研究的目的:

调查长期臭氧暴露与视网膜微血管变化之间的关联.
探索加速视网膜衰老作为臭氧-脑心血管风险通路中介者的作用.
量化臭氧对特定视网膜血管参数和视网膜年龄差距 (RAG) 的影响,在大型T2DM队列中.

主要方法:

在上海 (2017) 招募了55463名T2DM患者的队列.
使用卫星数据 (1x1公里分辨率) 估计了五年 (2013-2017年) 的平均臭氧暴露.
视网膜血管特征 (CRAE,CRVE,AVR,VT,Df) 和RAG使用多变量回归和双重机器学习进行分析,并采用调解分析.

主要成果:

增加的臭氧暴露与中枢视网膜动脉等值 (CRAE),中枢视网膜静脉等值 (CRVE),血管形 (VT) 和碎形尺寸 (Df) 的下降相关.
臭氧增加10μg/m3与RAG的2.29年增加有关.
调解分析表明,加速衰老部分解释了臭氧暴露与CRAE,CRVE和Df减少之间的关联.

结论:

长期暴露于臭氧与视网膜衰老加速和微血管重塑有关,包括血管缩小和简化.
这些发现提供了新的生物学证据,支持臭氧暴露与心血管风险增加之间的因果关系.
视网膜的微血管变化和加速衰老可能是介导空气污染对心血管健康的不良影响的关键途径.

关键词:

衰老的衰老衰老的衰老糖尿病糖尿病糖尿病微血管系统是一个微血管系统.臭氧臭氧是什么?臭氧臭氧是一种视网膜血管视网膜血管

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