纳米塑料对甲状腺功能的影响:揭示细胞生动力学,分子机制和人类风险评估
Patricia Iglesias-Hernandez1, Jose Vicente Tarazona2, Juliana Manosalva3
1Tumor Endocrine Unit, Chronic Disease Program (UFIEC), Instituto de Salud Carlos III, Ctra. Majadahonda a Pozuelo km 2.2, Madrid 28220, Spain; Environmental Toxicology Unit, National Environmental Health Centre (CNSA), Instituto de Salud Carlos III (ISCIII), Ctra. Majadahonda-Pozuelo Km. 2,2., Majadahonda, Madrid 28220, Spain; PhD Programme on Biomedical Sciences and Public Health (ISCIII-UNED), Universidad Nacional de Educación a Distancia, Madrid 28040, Spain.
Journal of hazardous materials
|September 20, 2025
概括
聚乙烯纳米塑料 (PSNP) 通过改变激素平衡和吸收来破坏甲状腺功能. 这些内分泌干扰物对甲状腺疾病和神经发育构成风险,需要采取监管措施.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 纳米塑料 (NP) 是新兴的环境污染物,其内分泌干扰潜力基本未知.
- 聚乙烯纳米塑料 (PSNP) 普遍存在,引发了人们对其对人类健康,特别是甲状腺功能的影响的担忧.
研究的目的:
- 为了研究PSNP对甲状腺衍生细胞系的影响.
- 阐明PSNP影响的细胞生动力学,氧化还原平衡和甲状腺激素 (TH) 相关的基因和蛋白质表达.
主要方法:
- 利用甲状腺衍生细胞系研究PSNP内部化,局部化和清除.
- 评估了氧化还原平衡,吸收和TH相关基因/蛋白质表达的变化 (例如,NIS,MCT8).
- 计算了NIS基因抑制的基准剂量 (BMD5).
主要成果:
- PSNP被快速内化并局部化在溶酶体和内分泌网膜中,清除程度有限.
- 在没有明显的细胞毒性的情况下观察到与TH相关的转录中的时间和度相关的变化.
- PSNP提高了ROS水平,降低了的吸收,并破坏了TH平衡,在11颗粒子/细胞时,对NIS抑制的BMD5有影响.
结论:
- 确定PSNP是具有甲状腺特异性影响的内分泌干扰剂,有助于甲状腺功能低下和神经发育受损.
- 证明了PSNP破坏甲状腺生理和平衡的潜力.
- 强调需要采取监管行动,并整合NP风险评估的新方法方法.
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