相关实验视频

Updated: Jul 20, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

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在前运动表现的亨廷顿病中脑ATP降低:试点研究

Lindsay E Golden1, Jia Xu2, Vincent A Magnotta3

  • 1Carver College of Medicine at the University of Iowa, Department of Psychiatry, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

Parkinsonism & related disorders
|September 20, 2025
PubMed
概括

亨廷顿氏病 (HD) 患者的ATP水平比健康个体低. 较低的ATP与疾病严重程度相关,这表明ATP测量是HD的潜在生物标志物.

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Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

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A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease05:39

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相关概念视频

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...