患有新生儿脑病变的新生儿中与失糖症相关的神经生理学变化
Jessy Parokaran Varghese1, Elana F Pinchefsky2, Saeed Montazeri3
1Neurosciences and Mental Health Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
概括
高血糖症,而不是低血糖症,与新生儿患有新生儿脑病症的新生儿经历治疗性低温症的脑活动变化有关. 这表明高葡萄糖可能会恶化脑损伤.
科学领域:
- 新生儿神经学 新生儿神经学
- 神经生理学 神经生理学
- 内分泌学 在内分泌学.
背景情况:
- 新生儿脑病变 (NE) 是新生儿的一种严重疾病.
- 治疗性低温 (TH) 是对NE的标准治疗方法.
- 在TH期间血糖水平对大脑功能的影响尚未完全理解.
研究的目的:
- 为了检查血糖异常 (低血糖和高血糖) 与电脑电图 (EEG) 测量之间的关联,该测量是在用TH治疗的NE的新生儿中进行的.
主要方法:
- 96名接受TH治疗的NE新生儿在48小时内进行了持续的葡萄糖监测 (CGM) 和EEG.
- 在低血糖和高血糖时期分析了EEG数据以获得视觉背景得分和22项计算措施.
- 分析根据缺氧-缺血症的严重程度进行了调整.
主要成果:
- 高血糖时期与明显更差的视觉EEG背景得分和11个计算EEG测量相关.
- 低血糖时代与视觉EEG背景得分没有显著的关联,只与一个计算EEG测量相关.
结论:
- 高血糖暂时与新生儿的脑功能变化有关,新生儿有NE接受TH.
- 这些发现表明,葡萄糖水平升高可能直接导致这一群体的脑损伤.
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