冠心病归因于工作中的心理社会压力因素
Mathilde Lavigne-Robichaud1, Xavier Trudel2, Denis Talbot2
1Population Health and Optimal Health Practices Research Unit, CHU de Québec-Université Laval Research Center, Québec City, QC, Canada.
JACC. Advances
|September 20, 2025
概括
心理社会压力因素,如工作压力和努力回报失衡 (ERI),对冠状动脉疾病 (CHD) 事件有显著的贡献. 解决工作场所的压力可能会减少心脏病的整体负担.
科学领域:
- 职业健康 职业健康 职业健康
- 心血管流行病学心血管流行病学
- 心理社会风险因素 心理社会风险因素
背景情况:
- 工作中的心理社会压力因素,如工作压力和努力回报失衡 (ERI),与冠状动脉疾病 (CHD) 风险增加有关.
- 在前性研究中,量化可归因于这些工作场所暴露的CHD事件的比例至关重要.
研究的目的:
- 估计冠心病 (CHD) 事件中可归因于工作中的心理社会压力因素的比例.
- 利用20年的前性队列研究来评估工作压力和ERI对心脏病发病率的影响.
主要方法:
- 北克市6295名员工 (2004-2018) 的前性队列研究,不包括以前患有心血管疾病的人.
- 通过验证的仪器评估工作压力和ERI;通过医疗保健数据库识别CHD事件.
- 采用卡普兰-梅尔法用于可归因的分数,用多次归算和反向概率权重用于混和选择偏差,不包括前5年以尽量减少反向因果关系.
主要成果:
- 在15年内,发生了669次心血管疾病事件 (发生率:5.96/1,000人/年).
- 工作压力与18.2%的冠心病事件 (95%CI:1.8%-34.7%) 的可归因部分有关.
- 工作压力和ERI的联合暴露占了19.5%的CHD事件 (95%CI:0.7%-38.4%).
结论:
- 工作中的综合心理社会压力因素 (工作压力和ERI) 在这个队列中约占冠心病事件的五分之一.
- 调查结果强调工作场所的心理社会因素是预防心血管疾病战略的潜在目标,以减少疾病负担.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
405
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
405
Stress and Mental Health
810
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
810
Psychological Responses to Stress
485
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
485
Introduction to Stress and Lifestyle
517
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
517
Components of Stress
504
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
Interestingly, the hidden cube faces also experience these stresses, equal and...
504
Coronary Artery Disease IV: Preventive Measures
590
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
590


