埃梅里亚菌种群的影响. 和金黄色葡萄球菌对 brojlers 中的 cecal 微生物群的挑战
Venkata Sesha Reddy Choppa1, Hamid Reza Rafieian Naeini1, Daniel Junpyo Lee2
1Department of Poultry Science, University of Georgia, Athens, GA, United States.
Poultry science
|September 20, 2025
概括
黄金葡萄球菌和埃梅里亚种类. brojlers 的同时感染显著改变 cecal 微生物群,增加的风险. 这些变化取决于剂量和时间,强调需要针对微生物群的策略来预防细菌性慢性病变和骨髓炎 (BCO).
科学领域:
- 禽类健康与微生物学
- 鸟类肠道微生物组的动力学
- 细菌性淋巴结裂和骨髓炎 (BCO) 病原发生
背景情况:
- 黄金葡萄球菌是 brojlers 的首要原因,通常与细菌性冠状炎和骨髓炎 (BCO) 相关.
- 肠道健康问题,包括由Eimeria物种引起的菌病,经常与 brojlers. aureus感染并存.
- 黄金菌和埃梅里亚菌对 brojler cecal microbiome 的影响仍然不太清楚.
研究的目的:
- 为了研究受 Staphylococcus aureus (S. aureus) 和 Eimeria 种类感染的 brojler 肉的 cecal 微生物组的变化.
- 为了阐明S. aureus暴露对肠道微生物群体的剂量和时间依赖的影响.
- 确定菌微生物组变化与细菌性慢性病变和骨髓炎 (BCO) 的致病性之间的潜在联系.
主要方法:
- 一天大的雄性科布肉被施加不同剂量和时间的S. aureus挑战.
- 一种混合的Eimeria spp. 挑战对大多数治疗组进行了管理.
- 在化后的20日和26日,使用16S rRNA基因测序分析了的含量.
主要成果:
- 在应对S. aureus和Eimeria共同挑战时,观察到菌微生物群的α和β多样性的显著变化.
- 高度或重复的S. aureus暴露导致显著的微生物转移,包括Actinobacteria,Microbacteraceae和Leuconostocaceae的变化.
- 功能性通路分析表明,脂质代谢和免疫信号通路的变化,可能有助于BCO的发病.
结论:
- 同时感染Eimeria和S. aureus会显著改变肉肉微生物群,这种方式取决于剂量和时间.
- 这些微生物变化与与骨健康相关的途径有关,这表明对BCO的倾向.
- 准肠道微生物组是缓解家禽骨问题和的有希望的策略.
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