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Updated: Jan 17, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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马特林-3形成球形和类似虫的组件,由RNA结合和ALS/FTD相关突变调节

Macy L Sprunger1, Min Kyung Shinn2, Sabrina K Talir1

  • 1Department of Chemistry, Washington University, St. Louis, MO 63130, USA.

Molecular cell
|September 20, 2025
PubMed
概括

马特林-3 (MATR3),一种与ALS/FTD相关的RNA结合蛋白,形成独特的纳米级组件. 它的结构驱动着度依赖的球体-虫过渡,由RNA和疾病突变调节.

关键词:
这就是Matrin-3的意义.这是一种RNA结合蛋白质.在TDP-43中使用.骨髓缩侧面硬化症 (ALS) 是一种疾病.生物分子凝聚剂是生物分子的凝聚物.本质上是无序的蛋白质.阶段分离的阶段分离.

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