生命早期的压力和母亲的免疫激活改变了年轻雄性大鼠的应对压力行为和大脑代谢活动
Saúl Sal-Sarria1, Héctor González-Pardo1, Nélida M Conejo1
1Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Oviedo, Spain; Institute of Neurosciences of the Principality of Asturias (INEUROPA), Oviedo, Spain; Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain.
Physiology & behavior
|September 20, 2025
概括
早期的压力和母亲的免疫激活协同增加焦虑和改变大脑新陈代谢,可能增加对情绪障碍的脆弱性. 联合侮辱会影响应对压力和大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 环境心理学 环境心理学
- 发育生物学 发展生物学
背景情况:
- 早期生活压力 (ELS) 和孕产妇免疫激活 (MIA) 是已确定的情绪障碍的风险因素.
- 对于ELS和MIA对情感行为和大脑新陈代谢的综合影响尚不清楚.
研究的目的:
- 研究MIA和ELS对雄性大鼠的情感行为和大脑氧化代谢的独立和相互作用影响.
- 探索ELS和MIA联合暴露的神经生物学基础.
主要方法:
- 怀孕期间通过LPS注射诱导的MIA;通过产后母亲分离的ELS.
- 行为评估包括高空零迷宫和强迫游泳测试.
- 大脑氧化代谢通过细胞染色体c氧化酶 (CCO) 基因化学测量在关键大脑区域.
主要成果:
- MIA增加了类似焦虑的行为;ELS减少了运动运动活动.
- 在强迫游泳测试中观察到MIA和ELS的协同效应,增加了不移性.
- 无论是MIA还是ELS,都独立地在皮下区域 (包括杏仁体和海马体) 增加了CCO活性.
结论:
- MIA和ELS对应对压力行为和大脑氧化代谢产生协同效应.
- 对妊娠期免疫挑战和早期产后压力的联合暴露可能会增加对成人情绪障碍的易感性.
- 与情感和动机相关的大脑区域的干扰是观察到的神经行为变化的基础.
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