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一个用于核酸药物输送的通用纳米平台:从分子结合到抗病毒疗法

Zheng Zhou¹, Fan Zhang², Xiang Li¹

¹School of Nano-Technology and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, Jiangsu Province, China.

Journal of controlled release : official journal of the Controlled Release Society

|September 20, 2025

概括

研究人员开发了一种新型的聚合物纳米粒子载体 (PGB),用于输送核酸三酸盐 (TP),增强细胞吸收和对病毒感染的抗病毒功效. 这种纳米载体平台显示了基于核酸的治疗方法的前景.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

基于核酸的治疗药物对于治疗病毒感染和癌症至关重要.
核三酸盐 (TPs),活性药物形式,由于高极性和负电荷,在细胞吸收方面面临挑战.
现有的前药物策略通常具有有限的激活和有效性.

研究的目的:

开发一种高效的纳米载体系统,用于细胞内输送水性核酸三酸盐 (TPs).
创建一个聚合物载体 (PGB),能够有效地结合和传递TP.
评估PGB纳米载体系统增强的抗病毒功效和药物动力学特征.

主要方法:

设计了一种聚合物载体 (PGB) 与相交替的酸和基组,用于多价值结合核酸基因.
使用关联常数量化了PGB与ATP的结合亲和力.
在病毒感染模型中测试了PGB纳米粒子配方,包括H1N1感染的小鼠模型,并将其性能与Molnupiravir进行了比较.

主要成果:

该PGB载体表现出强大的结合亲和力 (K_a高达5.19 × 10⁸) 与ATP在生理pH.
纳米颗粒配方促进了TPs的高效细胞质输送.
与Molnupiravir相比,在感染H1N1的小鼠中,PGB纳米颗粒改善了药理动力学,抑制了病毒复制,减少了肺炎,并保留了肺功能.

结论:

PGB聚合物载体成功实现了高效的加载和细胞内输送水利核酸三酸盐.
这种纳米载体平台为核酸药物输送提供了多功能和广泛适用的解决方案.
这项研究强调了一项有希望的策略,以提高基于核酸的治疗药物的疗效.

关键词:

抗病毒纳米粒子抗病毒纳米粒子这种H1N1流感是什么?纳米医学是一种纳米医学.核类药物核类药物在PBAE聚合物聚合物中,

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