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基于桑坦的纳米复合物:调节体性质,模型化合物封装和粘附通过二甲基胺基甲基德克斯

Ioannis Pispas¹, Ewa Pavlova², Miroslav Slouf²

¹Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635, Athens, Greece; Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Heroon Polytechniou 9, Zografou, 15780, Athens, Greece.

International journal of biological macromolecules

|September 20, 2025

概括

赞坦和二甲基氨基乙德克斯形成稳定的纳米复合物,适用于疏水性药物输送. 这些粘粘性纳米颗粒显示可调节的特性和高封装效率,如β-胡卜素的化合物.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
纳米技术纳米技术

背景情况:

赞坦 (XG) 和二甲基氨基乙烯 (DD) 是生物相容的多糖.
静电复合是一种创建新型纳米材料的有希望的方法.
开发具有可控性质的稳定纳米粒子对于药物输送至关重要.

研究的目的:

准备和表征的静电纳米复合物 (NCs) 的桑坦和二甲基乙烯.
为了研究电荷比率和桑坦脱化对NC属性的影响.
评估这些NCs在疏水性化合物封装和粘膜粘合方面的潜力.

主要方法:

动态和静态光散射 (DLS和SLS) 用于大小和形状分析.
传输电子显微镜 (TEM) 用于可视化纳米粒子形态.
光光谱学 (pyrene和ANS) 来探测疏水性领域.
用β-胡卜素 (β-C) 进行封装研究.
使用猪胃粘素 (PGM) 溶液和酸珠进行粘粘度测试.

主要成果:

精确定义的,球形XG/DDNCs (100-200nm) 在一系列的电荷比率 (0.4-5) 中形成.
在电荷比>1时,NC大小增加,可能是由于XG双螺旋形成.
在NC中存在疏水域,促进β-C封装 (高达48%的效率).
原生XGNCs显示比变质XGNCs显著更高的β-C负载.
NCs在一个月内表现出稳定性,并表现出粘膜粘合性,增强了正面电荷.

结论:

桑坦/二甲基氨基乙烯德克斯NCs提供可调的物理化学特性.
这些NC是稳定的,并且具有适合封装疏水药物的疏水域.
该NC的粘膜粘合性表明有针对性的药物输送应用的潜力.

关键词:

粘液类同类物质的粘液类同类物质粘液可以模仿粘液.聚糖胺纳米凝是一种多糖化合物.聚糖胺纳米粒子聚糖胺纳米粒子这是一种β-胡卜素.

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