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使用半固体挤出3D打印制造的聚合物制药输送系统,长期控制的FITC-dextran体外释放

Juuso Pohjola¹, Mika Jokinen², Tero Soukka³

¹Biotechnology, Department of Life Technologies, Faculty of Technology, University of Turku FI-20014 Turku, Finland; Pharmaceutical Sciences, Bayer Oy, FI-20210 Turku, Finland.

International journal of pharmaceutics

|September 20, 2025

概括

这项研究引入了一种新的3D打印方法,用于个性化可控释放药物递送系统. 该技术允许通过调整油墨成分和后处理条件来定制宏分子药物释放配置文件.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
制药科学制药科学

背景情况:

控制释放药物递送提高了治疗疗效和患者的服药性.
个性化医疗需要定制的药物输送系统,3D打印可以提供.
现有的3D打印方法难以控制大分子药物的释放.

研究的目的:

开发一种3D打印方法,用于创建个性化,大分子释放聚合物基础的药物递送系统.
调查油墨成分和后处理对药物释放和材料降解的影响.
通过半固体挤出3D打印来证明量身定制的药物释放配置文件的潜力.

主要方法:

半固体挤出3D打印被用来制造基于聚合物的药物输送系统.
光素异硫酸-德克斯 (一种模型大分子药物) 被封装在PLGA微球中.
微球被纳入卡博波尔凝基墨水中,打印成圆柱形模型,并用溶剂蒸汽后处理以控制孔隙性.
在三个月内监测了体外降解和药物释放.

主要成果:

系统的多孔性显著影响了爆裂释放和聚合物降解率.
药物释放可以通过修改油墨组成和后处理来加速,减缓,延迟或阻止.
开发的3D打印方法成功创建了用于控制大分子药物释放的系统.

结论:

本次介绍的半固体挤出3D打印方法为开发针对大分子药物的个性化控制释放系统提供了一种可行的方法.
量身定制油墨配方和后处理可以精确控制药物释放动力学.
这项技术对推进宏分子药物递送应用有前途.

关键词:

通过3D打印打印3D打印.乙酸盐是什么乙酸盐是什么卡博波尔 (Carbopol® Ultrez 10 NF) 是一种天然制剂.有控制释放的释放.二甲二甲二甲是一种甲基二甲基硫氧化物二甲基硫氧化物在FITC-dextran中使用.光素异硫酸盐-德克斯兰微球微球是指微球的小部分.在 PLGA PLGA 中.聚 ((乳酸-co-glycolide) 是一种聚乳酸的化合物.半固体挤出方式半固体挤出方式亚酸是一种酸.氧化是什么? 氧化是什么?甲基氨酸四.

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