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Updated: Jan 17, 2026

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构成性安德罗斯坦受体激活通过ubiquitination和sumoylation调节YAP表达和活性

Fengting Liang1, Shuaishuai Zhang1, Wenhong Zhou1

  • 1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Toxicology letters
|September 20, 2025
PubMed
概括

构成性安德罗斯坦受体 (CAR) 激活通过修改Yes相关蛋白 (YAP) 后翻译修改来影响Hippo通路. 通过K63链接的无化和SUMO1修饰,CAR促进YAP的核转移,影响肝脏的再生.

关键词:
构成的安德罗斯坦受体.后翻译修改后的修改.蛋白质相互作用 蛋白质相互作用这就是SUMO1的意义.在Ubiquitination中使用.是的 - 相关蛋白质.

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