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初级毛的完整性决定了TRPV4介导的NF-κB/COL2信号传递在骨关节炎的发病过程中

Yuyan Sun1, Ziyu Luo1, Haiqi Zhou2

  • 1Department of Rehabilitation, The Second Xiangya Hospital, Central South University, Changsha 410000, China.

Cellular signalling
|September 20, 2025
PubMed
概括

初级毛对于感知软骨中的机械力量至关重要. 它们在骨关节炎 (OA) 中的丧失会破坏TRPV4通道功能,影响NF-κB和原生成,突出IFT88作为OA的潜在治疗标.

关键词:
信号通路中的.西里亚 (Cilia) 是一个小体.在 NF-κBB 中.骨关节炎是一种骨关节炎.在 TRPV4 频道上播放.第二种类型的原.

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