在弱势群体中,使用电子烟或不使用电子烟的极低尼古丁含量香烟对心肺的影响
Katherine E Menson1, Diann E Gaalema2, Brian R Katz2
1UVM Tobacco Center of Regulatory Science, University of Vermont, Burlington, VT, USA.
非常低尼古丁含量香烟 (VLNCs) 与偏好的风味电子烟相结合并没有影响客观的心肺测量. 然而,这种组合可能会使一些高风险个体的咳严重程度恶化.
科学领域:
- 公共卫生 公共卫生
- 心肺健康 心肺健康
- 药物成科学 药物成科学
背景情况:
- 戒烟是一项公共卫生优先事项.
- 尼古丁减少策略,包括极低尼古丁含量香烟 (VLNCs),显示出希望.
- 电子烟的作用,特别是喜欢的风味,与VLNC一起用于减少吸烟需要研究.
研究的目的:
- 评估单独使用VLNC和与易受伤害的人群结合使用电子烟对心肺的影响.
- 将VLNC与普通尼古丁含量香烟 (NNC) 和不同的电子烟配置 (烟草风味与首选风味) 进行比较.
主要方法:
- 三项涉及弱势群体的随机对照试验 (受教育程度较低的女性,阿片类药物使用障碍患者,情绪障碍患者).
- 参与者被分配到NNC,只有VLNC,VLNC + 烟草风味电子烟,或VLNC + 首选风味电子烟16周.
- 心肺结局包括生命体征,主观呼吸道症状,并使用多变量线性混合模型进行分析.
主要成果:
- 在实验条件之间没有观察到客观心脏或肺部测量的显著差异.
- 与单独使用VLNC或VLNC+烟草风味电子烟相比,正常尼古丁含量香烟 (NNC) 和VLNC +首选风味电子烟组中的主观咳严重程度评级显著更高.
- 这种效应在参与者中特别明显,这些参与者先前患有呼吸道疾病.
结论:
- 将VLNC与偏好的风味电子烟相结合不会对客观的心肺健康指标产生不利影响.
- 在某些高风险肺部亚群体中,使用VLNC与喜欢的风味电子烟时,咳严重性的主观报告可能会增加.
- 需要进一步的研究,以了解尼古丁减少策略对呼吸系统健康的微妙影响.
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