孕产妇的饮食炎症指数和出生时炎症的生物标志物
Courtney Dow1, Rosalie Delvert2, Blandine de Lauzon-Guillain1
1Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, Île-de-France, France.
根据能量调整的饮食炎症指数 (E-DII) 评估,怀孕期间母亲的饮食没有显示出在出生时带血或母亲血清中炎症生物标志物的相关性. 这表明饮食的炎症潜力可能不会影响婴儿炎症标志物.
科学领域:
- 围产期营养学 围产期营养学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 怀孕期间母亲的饮食可以影响胎儿的发育和免疫编程.
- 带血液和母体血清中的炎症生物标志物是全身炎症的指标.
- 能量调整的饮食炎症指数 (E-DII) 量化了饮食的炎症潜力.
研究的目的:
- 调查怀孕期间母亲饮食的炎症潜力与出生时的炎症生物标志物水平之间的联系.
- 为了确定怀孕期间的E-DII得分是否与新生儿和母亲的特定炎症标志物相关.
主要方法:
- 利用了来自法国EDEN和ELFE出生队伍的数据.
- 计算了怀孕期间母亲饮食的E-DII得分.
- 在带血液和母亲血清中测量了炎症生物标志物 (IL-1β,IL-6,IL-10,TNF-α,瘦素,C反应蛋白).
- 采用调整后的线性回归模型来分析E-DII三角形和生物标志物度之间的关联.
主要成果:
- 在任何一个队列中,E-DII得分和母亲血清或带血炎症生物标志物之间没有发现显著的关联.
- 特定的炎症标志物包括互乐金-1β,互乐金-6,互乐金-10,瘤缩因子-α,丁和C反应蛋白与饮食炎症潜力没有相关性.
结论:
- 在怀孕期间的能量调整的饮食炎症指数得分与出生时母亲血清或带血中炎症生物标志物的度无关.
- 通过E-DII测量母亲的饮食炎症潜力,似乎不是新生儿在出生时炎症状况的重要决定因素.
更多相关视频
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
相关概念视频
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
