一个年轻人的大麻诱导心脏骤停:一个案例报告
Sana Irshad1, Parth Adrejiya1, Mohammad Abubaker1
1Department of Internal Medicine, WellStar Spalding Health System, Griffin, GA, USA.
The American journal of case reports
|September 21, 2025
概括
大麻中的四大麻 (THC) 即使在年轻成年人中也可能导致严重的心脏问题,如心室动和QTc延长. 这一案例凸显了大麻引起的心脏毒性的风险,强调了临床意识的必要性.
科学领域:
- 心脏病学 心脏病学
- 毒理学 毒理学 毒理学
- 大麻素研究 研究 大麻素研究
背景情况:
- 大麻的主要精神活性成分四大麻 (THC) 越来越多地用于娱乐目的,特别是年轻人.
- 尽管人们普遍认为THC是安全的,但新兴的研究将THC使用与严重的心血管并发症联系起来.
- 这些并发症包括QTc间隔延长,心室节律失常和心脏骤停,即使在没有先前心脏病的个体中也是如此.
研究的目的:
- 报告年轻人患有慢性大麻使用的突然心脏骤停病例.
- 突出大麻使用诱导危及生命的心律失常和QTc延长的潜力.
- 强调在临床实践中考虑大麻诱导的心脏毒性的重要性.
主要方法:
- 一个26岁的女性在慢性大麻使用后出现心脏骤停的病例报告.
- 最初的评估包括先进的心脏生命支持,心电图 (ECG) 和尿液药物查.
- 随后的调查包括心脏导管和评估左心室喷射率.
主要成果:
- 患者经历了心室动,需要复苏.
- 最初的心电图显示鼻高心率与延长的QTc间隔 (483毫秒);尿液药物查结果为THC阳性.
- 心脏导管检查显示冠状动脉正常,左心室喷射率随着时间的推移而正常化.
- 患者患有缺氧缺血性脑损伤,需要康复.
结论:
- 大麻使用,特别是THC,可以在没有先前心血管风险因素的年轻人中导致严重的心脏事件,包括心室动和QTc延长.
- 这一案例强调了大麻诱导心脏毒性的潜力.
- 临床医生应保持与大麻相关的心脏并发症的高怀疑指数,因为大麻使用的流行率不断上升.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
1.1K
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
1.1K
Drug Toxicity: Risk factors
229
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
229
Coronary Artery Disease III: Clinical Manifestations
620
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
620
Introduction Cardiac Emergencies
565
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
565
Cardiopulmonary Resuscitation I: Adult
1.3K
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
1.3K
Cardiopulmonary Resuscitation IV: Pharmacological Management
1.6K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.6K


