食物过敏原与多糖相互作用:结构,表征,消化和过敏性
Wanglong Yu1, Wei Hu1, Ziwen Hao1
1State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China; College of Food Science and Technology, Nanchang University, Nanchang 330031, China.
Food chemistry
|September 21, 2025
概括
多糖在通过与过敏原相互作用来对抗食物过敏方面表现有前途. 它们改变过敏原的结构和消化能力,并影响免疫反应和肠道微生物群,以潜在的抗过敏应用.
科学领域:
- 食品科学 食品科学 食品科学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 全球食品过敏患病率不断上升,需要新的抗过敏策略.
- 多糖类具有结构多功能性和与过敏调节相关的生物活性性质.
- 了解多糖与过敏原的相互作用是制定饮食干预措施的关键.
研究的目的:
- 审查多糖和过敏原的特性.
- 阐明多糖与过敏原相互作用的机制.
- 为了探索多糖的抗过敏潜力.
主要方法:
- 关于多糖类的分类,结构和性质的文献综述.
- 对多糖和过敏原之间的共价和非共价相互作用的分析.
- 检查多糖对过敏原结构,表位和消化能力的影响.
- 审查涉及免疫细胞调节和肠道微生物群改变的间接机制.
主要成果:
- 多糖类可以通过糖化改变过敏原的二次结构和表位.
- 聚糖蛋白凝的形成降低了过敏原的消化能力和过敏原活性.
- 多糖通过调节免疫细胞和肠道微生物群多样性来间接调节过敏反应.
结论:
- 多糖为抗过敏策略提供了一个有希望的途径.
- 机制包括直接修改过敏原和间接免疫/微生物群调节.
- 本综述为开发抗过敏饮食成分提供了理论基础.
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