牛作为抗生素耐药基因的来源:用印度各州的样本进行案例研究
Vijay Laxmi Shrivas1, Anil Kumar Choudhary2, Puttaswamy Hariprasad3
1Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, 110016, India; Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi, 110016, India.
The Science of the total environment
|September 21, 2025
概括
印度牛中的抗生素耐药性 (AMR) 普遍存在,与营养水平和地理位置有关. 这凸显了迫切需要制定战略,防止AMR从动物废物传播到环境中,并保护公众健康.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 抗生素耐药性 (AMR) 是一个全球公共卫生威胁,印度因其人口,农业和医疗保健而面临更高的风险.
- 印度畜牧业的大量抗生素消费和不充分的法规,特别是关于动物废物的法规,导致了AMR的担忧.
- 关于动物废物中AMR的流行情况的数据有限,需要对其环境传播进行研究.
研究的目的:
- 调查印度各地区牛中AMR的分布模式.
- 确定肥料的物理化学特性,细菌负载和抗生素耐药性基因 (ARG) 的存在之间的相关性.
- 评估地理因素对牛排废物中抗菌素耐药性流行的影响.
主要方法:
- 从印度四个州和一个联邦领土收集了74个牛样.
- 分析样本以检测ARG和移动遗传元素的存在.
- 将细菌和ARG的丰度与物的生理参数和地理位置相关联.
主要成果:
- 在所有采样地点检测到ARG和移动遗传元素.
- 在肥营养水平 (,) 和特定的AMR概况之间观察到正相关性.
- 细菌种群和ARG患病率受到地理位置的显著影响.
结论:
- 牛是AMR在环境中的重要储存和潜在传播源.
- 营养含量和地理因素在塑造牲畜废物中的抗菌素耐药性模式方面起着至关重要的作用.
- 基于证据的策略对于控制牲畜废物传播的抗菌素耐药性和保护公共卫生至关重要.
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