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摩格罗化物V:分子机制和治疗应用

Yun-Long He¹, Pan Hu², Hou-Lin Xia³

¹Chengdu Institute of Chinese Herbal Medicine, Chengdu 610016, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|September 21, 2025

概括

来自Siraitia grosvenorii的Mogroside V (MV) 通过向关键信号通路,显示出对各种疾病的治疗潜力. 为了临床应用,需要进一步的研究.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

摩格化物V (MV) 是Siraitia grosvenorii中的一个关键的生物活性化合物.
MV对氧化应激,炎症,骨质疏松症,糖尿病,肥胖和神经系统损伤有治疗作用.
缺乏对MV的分子机制和治疗途径的全面审查.

研究的目的:

系统地审查和总结了解Mogroside V (MV) 的分子机制的最新进展.
通过分析其对核心信号通路的影响,阐明MV的治疗潜力.
巩固有关MV多面生物功能的当前知识.

主要方法:

在PubMed,科学网络和谷歌学者中进行文献搜索.
基因和基因组的京都百科全书 (KEGG) 途径分析使用.
探索MV对各种疾病模型的作用机制.

主要成果:

MV通过JAK/STAT,PI3K/Akt/mTOR,TLR4和ERS-UPR通路产生抗炎作用.
MV的抗氧化特性通过Nrf2/HO-1,PI3K/Akt和SIRT通路进行介导.
MV通过准肥胖的AMPK,糖尿病的PI3K/Akt/GLUT2和骨质生成的TUG1来影响新陈代谢.

结论:

莫格洛V (MV) 显示出作为多目标治疗剂的潜力.
建议对MV的生物可用性和临床转化进行进一步的研究.
MV复杂的分子机制为疾病治疗提供了有前途的途径.

关键词:

抗炎药物抗炎药物抗炎药物糖尿病糖尿病糖尿病效果机制的影响机制.莫格罗赛德V 类型骨质疏松症是一种骨质疏松症.药理学效应药理学效应是一种药理学效应.

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