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具有高强度柔性,大面积电腐蚀,抗菌,血管新生和骨质整合能力的Fe/Zn复合材料,用于可生物降解的骨固定应用

Xian Tong¹, Yue Han², Lanxin Gu²

¹Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.

|September 21, 2025

概括

通过热挤压制造的新型铁/ (Fe/Zn) 复合材料提供了增强的机械性能和适合生物降解骨固定的降解率. 这种先进的材料在体外和体外表现出卓越的生物性能,包括骨再生和抗菌作用.

科学领域:

生物材料工程生物材料工程
整形外科植入物整形外科植入物
材料科学材料科学材料科学

背景情况:

可生物降解的Fe/Zn复合材料由于潜在的加速降解,对骨固定有很大的希望.
制造具有最佳机械,腐蚀和生物特性的Fe/Zn复合材料仍然是一个挑战.

研究的目的:

开发一种创新的热挤压工艺,用于用于可生物降解的骨固定的Fe/Zn复合材料.
评估制造的Fe/Zn复合材料的机械,腐蚀和生物特性.

主要方法:

通过热挤出粉透的Fe泡制造Fe/Zn复合材料.
机械性能的表征 (拉力,压力强度,硬度,延长).
在汉克斯溶液中评估电化学腐蚀和降解率.
在体外评估细胞相容性,血管性,骨质分化和矿化.
在老鼠模型中对抗菌,抗炎,血管,骨质和骨质整合能力的体内评估.

主要成果:

与纯相比,热挤压 (HE) Fe/Zn复合材料的最终抗拉强度 (316.3 MPa),抗拉强度 (269.0 MPa),延长 (11.5%),压力强度 (275.3 MPa) 和硬度 (77.0 HB) 显著提高.
在汉克斯溶液中,HE Fe/Zn的腐蚀率为2466 μm/a,降解率为135.7 μm/a.
在体外研究表明了令人满意的细胞相容性,血管性,骨质分化和矿化.
在体内研究证实了抗菌性,抗炎性,血管性,骨质性和骨质整合能力,具有适当的降解率.

结论:

开发的热挤压Fe/Zn复合物是可生物降解的骨固定应用的有希望的候选物.
复合材料具有优越的机械强度,适当的降解特性和优良的生物活性,包括促进骨再生和表现出抗菌性质.

关键词:

血管新生机制的机制生物降解性生物降解性铁/合金复合材料在体内具有抗菌活性.骨质发生过程 (osteogenesis)

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