慢性鼻炎中肠道微生物组的变化:来自孟德尔随机化研究的见解
Ke-Shuang Wang1, Jun-Hao Tu2, Qian-Xing Wang3
1Southern Medical University, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Department of Otolaryngology and Head and Neck Surgery, Guangzhou, China.
Brazilian journal of otorhinolaryngology
|September 21, 2025
概括
慢性鼻炎 (CRS) 可能因果关系地影响肠道微生物组合,影响特定的细菌,如Haemophilus parainfluenzae和Bilophila. 肠道细菌和代谢途径的这些变化在CRS患者中需要更多的注意.
科学领域:
- 微生物组研究的研究.
- 遗传学 是一个遗传学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 肠道微生物组失调与各种疾病有关.
- 慢性鼻炎 (CRS) 与肠道微生物组之间的关系尚不清楚.
- 调查潜在的因果关系对于了解疾病机制至关重要.
研究的目的:
- 探索慢性鼻炎 (CRS) 和肠道微生物组失调之间的潜在因果关系.
- 为了确定CRS是否影响肠道微生物群的组成和代谢途径.
- 为了评估因果关系的方向性,使用双向门德尔随机化.
主要方法:
- 利用了来自FinnGen数据库的CRS的全基因组协会研究 (GWAS) 数据.
- 采用双样双向孟德尔随机化 (MR) 分析,使用来自荷兰微生物组项目的数据.
- 包括334,182名个人,并采用逆方差权衡 (IVW),加权中位数和其他MR方法.
- 进行敏感性分析以评估异质性和性.
主要成果:
- 前进MR建议CRS与Haemophilus parainfluenzae风险降低和Bilophila风险增加有关.
- CRS与肠道微生物群途径的改变有关,包括减少UDP-N-乙-d-葡萄糖胺生物合成I和从阿斯巴酸盐增加NAD生物合成I.
- 反向MR分析没有显示出显著的积极结果,表明CRS对肠道微生物群的主要影响.
结论:
- 慢性鼻炎 (CRS) 因果影响肠道微生物组合和相关代谢途径.
- 鉴定到的肠道微生物群的转变对患有CRS的患者来说是非常令人担忧的.
- 研究结果强调了在CRS管理中考虑肠道健康的重要性.
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