在使用-葡萄糖共运输体-2 抑制剂和甲胺的患者中,对玻璃眼的比较风险:一项跨国队列研究
Ssu-Yu Pan1, Chien-Hsiang Weng2, Shang-Feng Tsai3
1From the School of Medicine (S.Y.P., Y.J.S., C.C.C.), College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Ophthalmology (S.Y.P., C.C.C.), Taichung Veterans General Hospital, Taichung, Taiwan.
American journal of ophthalmology
|September 21, 2025
概括
与二型糖尿病 (T2DM) 患者的甲胺相比,-葡萄糖携带转运体-2 (SGLT2) 抑制剂显示眼睛高血压,初级开角玻璃眼 (POAG) 和玻璃眼药物治疗需求的风险较低. 这一发现表明,在T2DM管理中,对预防青光眼有潜在的益处.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2DM) 是一种全身性疾病,具有潜在的眼部并发症.
- 玻璃眼是导致不可逆转失明的主要原因,其与糖尿病的关联需要进一步调查.
- -葡萄糖共运输体-2 (SGLT2) 抑制剂和甲福林是常见的抗糖尿病药物,具有不同的作用机制.
研究的目的:
- 调查SGLT2抑制剂与甲福明对T2DM患者与青光眼有关的结局的比较影响.
- 评估患眼高血压的风险,初级开角玻璃眼 (POAG),以及需要服用玻璃眼药物的需要.
主要方法:
- 一项跨国,回顾性队列研究,涉及32,634名开始使用SGLT2抑制剂的患者和32,634名开始使用甲胺的患者.
- 根据各种临床因素,使用倾向性得分匹配来确保SGLT2抑制剂和甲福林组之间的可比性.
- 这项研究分析了眼睛高血压的发生率,POAG,以及5年内对青光眼的药物治疗需求.
主要成果:
- 与甲胺相比,SGLT2抑制剂与明显较低的眼睛高血压 (HR,0.73;95% CI,0.60-0.89),POAG (HR,0.64;95% CI,0.51-0.81) 和需要青光眼药物的风险相关 (HR,0.76;95% CI,0.69-0.84).
- 这些保护性关联在各种子组中一致,包括老年人 (≥60岁),女性,男性,白人患者和接受empagliflozin治疗的人.
结论:
- 与metformin相比,使用SGLT2抑制剂的治疗可能会在患有T2DM的患者中降低与玻璃眼相关并发症的风险.
- 这些发现强调了SGLT2抑制剂在T2DM综合管理中的潜在作用,包括眼睛健康.
- 需要进一步的前性研究来证实这些观察,并阐明底层机制.
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