在基于人口的研究中,肥胖和不活动是心力衰竭发展的最强风险因素
Bart J van Essen1, Nathalie Ang En Dan2, Ganash N Tharsana2
1University of Groningen, Department of Cardiology, University Medical Center Groningen, Groningen, the Netherlands.
International journal of cardiology
|September 21, 2025
概括
某些慢性疾病的组合显著增加心力衰竭 (HF) 的风险. 老年人,肺部疾病和肥胖/身体不活跃的群体显示出患高血压的风险最高.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 伴随性疾病与心力衰竭 (HF) 风险增加有关.
- 多发病性和它们与保留喷射分数 (HFpEF) 和减少喷射分数 (HFrEF) 的HF的特定关联仍未得到充分研究.
研究的目的:
- 在一个大群体中识别不同的多病症集群.
- 调查这些集群与事件HFpEF和HFrEF的差异关联.
主要方法:
- 隐性类分析被用来识别PREVEND队列中的6839名参与者中的多病态模式.
- 具有110,621人年随访的前性观察设计.
- 考克斯的比例危险模型被用来评估与事件HF的关联,并对混因素进行调整.
主要成果:
- 确定了六个多病症集群:年轻人,老年人,肺部疾病,精神,心理和肥胖/身体不活动.
- 与年轻群体相比,老年人,肺部疾病和肥胖/身体不活动群体的发生高血压风险明显高.
- 虽然HFrEF总体上更常见,但肥胖/身体不活动群体的发展HFpEF的可能性相对较高.
结论:
- 同病症形成了不同的群体,对HF风险产生不同的影响.
- 识别和解决这些多病态模式对于HF预防和管理至关重要.
更多相关视频
相关概念视频
Heart Failure I: Introduction
710
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
710
Pathophysiology of Heart Failure
3.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.0K
Heart Failure IV: Classification and Diagnostic Evaluation
323
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
323
Heart Failure II: Pathophysiology
734
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
734
Heart Failure VII: Nursing Interventions
422
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
422
Heart Failure VI: Adjunct Therapies
261
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
261


