3D打印的粘膜膜:为局部药物输送提供个性化药物剂量
Friederike Brokmann1, Sophia Grzam1, Jonas Fynn Kandzi1
1University of Greifswald, Institute of Pharmacy, Department of Biopharmaceutics and Pharmaceutical Technology, Centre of Drug Absorption and Transport, Felix-Hausdorff-Str. 3, D-17487 Greifswald, Germany.
概括
融合沉积建模 (FDM) 3D打印创建了具有明显药物和安慰剂部分的先进粘膜. 这种创新技术允许个性化剂量和特定地点的药物输送,为未来的治疗提供了一个多功能平台.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 粘膜膜提供非侵入性,局部化药物输送.
- 沉积建模 (FDM) 是一种先进的增材制造技术.
- 控制药物和安慰剂的放置是定制治疗的关键.
研究的目的:
- 调查使用双喷嘴FDM3D打印系统制造粘膜的使用情况.
- 为了比较FDM 3D打印薄膜的性能与通过溶剂造 (SC) 制造的薄膜.
- 通过使用多材料3D打印来评估个性化药物剂量和特定地点的输送潜力.
主要方法:
- 使用两个喷嘴的FDM3D打印系统制造粘膜膜,用咖啡因作为模型药物.
- 将3D打印片 (包括两部分verum/安慰剂设计) 与溶剂造片进行比较.
- 评估机械 (抗拉强度,伸展性),光学和溶解性能.
- 评估两种膜类型的粘膜粘合性.
主要成果:
- 与SC薄膜相比,3D打印的薄膜,特别是两部分设计,具有更高的抗拉强度,但灵活性较低.
- 无论是FDM还是SC方法,都产生了具有可比性粘膜特性的薄膜.
- 双喷嘴打印方法使药物 (verum) 和安慰剂部分的空间分离能够精确.
- 药物负载可以通过改变verum与安慰剂纤维的比率来调整.
结论:
- 多材料FDM3D打印是一种生产定制粘膜的多功能方法.
- 这项技术促进了特定地点的药物输送和个性化剂量策略.
- 这些发现支持3D打印粘膜膜在各种治疗应用中的潜力.
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