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2014-2024年期间在中国流通的人类腺病毒108型的基因分析

Jinjin Wang¹, Ling Jing², Yali Duan¹

¹Beijing Key Laboratory of Core Technologies for the Prevention and Treatment of Emerging Infectious Diseases in Children, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Virologica Sinica

|September 21, 2025

概括

人类腺病毒108型 (HAdV-108) 在中国持续传播,导致儿童严重急性呼吸道感染 (ARI) 和胃肠道症状. 这项研究突出了其遗传多样性和中国境内独特的流行病分支.

科学领域:

病毒学病毒学
分子生物学分子生物学
公共卫生公共卫生

背景情况:

人类腺病毒108型 (HAdV-108) 与全球儿童的严重急性呼吸道感染 (ARI) 有关.
关于HAdV-108的研究有限,特别是其在中国的临床和遗传特征.

研究的目的:

在中国的ARI儿童中调查HAdV-108的临床表现和遗传特征.
分析HAdV-108.8的进化动态和重组模式.

主要方法:

在中国 (2014-2024) 收集和测试来自ARI儿童的6720个呼吸道样本.
全基因组和主要囊蛋白 HAdV 隔离物的基因测序.
生物信息学和遗传学分析以确定遗传特征,进化和重组.

主要成果:

在6.62%的HAdV阳性样本 (21/317) 中检测到HAdV-108,在患病率上排名第三.
临床表现包括咳,发烧和胃肠道症状;在两个儿童中观察到严重的肺炎.
遗传学分析揭示了不同的国内流行病分支,其中一个新型菌株形成了一个独立的分支. 赫克森蛋白显示出高变异性,而纤维蛋白则被保存. 在基RGD循环中发现了三种氨基酸缺失.
确定了五种重组模式,HAdV-108表现出与其他物种C腺病毒相似的增殖能力.

结论:

在中国,HAdV-108是一种持久性病原体,在儿童中引起严重的肺炎和胃肠道问题.
集群3代表了HAdV-108在中国的主要流行分支.
显著的类型内遗传变异和多种复合事件是HAdV-108进化的特征.

关键词:

急性呼吸道感染 (ARI) 是一种急性呼吸道感染.孩子孩子孩子孩子临床特征临床特征遗传特征遗传特征遗传特征人类腺病毒108型 (HAdV-108)

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