微封装在老年人群中对益生菌对大脑结构和功能的影响有差异 - 一个随机的安慰剂受控试验
Julia Rode1, Ashley N Hutchinson1, Myrto S Chatzopoulou1
1School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro 70182, Sweden; Nutrition-Gut-Brain Interactions Research Centre, Örebro University, Örebro 70182, Sweden.
Brain, behavior, and immunity
|September 21, 2025
概括
像Lacticaseibacillus rhamnosus HN001这样的益生菌可能会影响老年人的大脑健康. 与非封装形式相比,微封装形式对视觉处理和血清素分布有不同的影响.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 老年学是一门学科.
背景情况:
- 肠-大脑轴在健康的衰老中起着至关重要的作用.
- 益生菌干预正在越来越多地探索它们对老年人的认知功能和大脑健康的影响.
研究的目的:
- 为了比较微封装与非封装Lacticaseibacillus rhamnosus HN001对老年人大脑功能和认知的影响.
- 研究益生菌配方对大脑形态测量,功能连接,认知表现和神经化学标记物的影响.
主要方法:
- 这是一项双盲,随机,安慰剂控制的研究,涉及87名社区居住的老年人 (60-80岁).
- 使用fMRI,大脑形态测量,认知测试 (处理速度,记忆) 和外周血清激素水平评估静止状态的功能连接.
- 微封装和非封装Lacticaseibacillus rhamnosus HN001组之间的比较.
主要成果:
- 在两个益生菌组之间观察到视觉处理区域的静止状态功能连接的显著差异 (p < 0.0001).
- 处理速度显示出显著的时间*组影响 (p <0.05),而短期记忆和焦虑症状没有显著的影响.
- 周围的血清素分布受到显著影响 (p < 0.05),但大脑形态测量,其他认知领域,抑郁,压力和睡眠质量没有受到影响.
结论:
- 益生菌的配方,特别是微封装,会影响它们对老年人大脑健康的影响.
- 微封装的益生菌可能与肠道产生不同的相互作用,从而对大脑功能产生不同的影响,特别是视觉处理和血清素通路.
- 这些发现凸显了益生菌输送系统在调节肠-大脑轴以实现健康衰老方面的重要性.
相关概念视频
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
229
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
229
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
197
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
197
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
232
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
232
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
238
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
238
01:15Drug Dosing: Geriatric Patients
228
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
228