在儿科肺动脉高血压中,右心房功能受损:多中心心血管磁共振研究
Kimberley G Miles1, Hieu T Ta1, Kurt R Bjorkman2
1The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
概括
儿科肺动脉高血压 (PAH) 显示右心房 (RA) 功能受损,扩张和相位功能变化预测不良事件. 标准的心血管磁共振成像 (CMR) 可靠地评估这些RA变化.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管成像 - 心血管成像
- 肺高血压研究 肺高血压研究
背景情况:
- 右心房 (RA) 功能受损预测肺动脉高血压 (PAH) 的成年人的不良结果.
- 在儿科PAH中RA功能尚不清楚.
- 这项研究研究了使用心血管磁共振成像 (CMR) 的儿科PAH的RA大小和功能.
研究的目的:
- 分析儿科PAH患者的RA大小和相位功能.
- 为了将RA指标与PAH严重程度相关联.
- 评估RA功能与儿科PAH中不良事件的关联.
主要方法:
- 对使用CMR.的儿科PAH患者和对照者的回顾性队列研究.
- 测量了RA体积和相位功能 (总体,导管,活性冲击体积,射出分数).
- 计算了新型A/C比率;与临床/血液动力学数据的相关性以及执行的不良事件.
主要成果:
- 与对照组相比,儿科PAH患者表现出较大的RA体积和改变的导管/活性相位功能.
- RA大小和活性功能与NT-proBNP,RV大小和填充压力相关.
- 雷性动脉管道喷射分数和A/C比率独立预测了儿科PAH的不良事件.
结论:
- 儿科PAH涉及RA扩张,导管功能减少和补偿性活性功能增加.
- 通过CMR进行RA大小和相位功能评估是可行的和可重复的.
- 这些RA指标对于评估PAH严重程度和预测儿童的结果非常有价值.
相关概念视频
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
418
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
418
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
223
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
223
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
414
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
414